Adeno-associated virus

Micro-dystrophin cDNA ameliorates dystrophic phenotypes when introduced into mdx mice as a transgene

Skeletal muscle biology / Fluorescence Microscopy / Gene Therapy / Immunohistochemistry / Western blotting / Transgenic Mice / Humans / Mice / Animals / Adeno-associated virus / Biochemical / Duchenne Muscular Dystrophy / Creatine Kinase / Phenotype / Skeletal Muscle / Time Factors / Dystrophin / Biochemistry and cell biology / Gene Transfer / Transgenic Mice / Humans / Mice / Animals / Adeno-associated virus / Biochemical / Duchenne Muscular Dystrophy / Creatine Kinase / Phenotype / Skeletal Muscle / Time Factors / Dystrophin / Biochemistry and cell biology / Gene Transfer

Adeno-associated virus vector-mediated gene transfer into dystrophin-deficient skeletal muscles evokes enhanced immune response against the transgene product

Immune response / Skeletal muscle biology / Gene Therapy / Biological Sciences / Mice / Female / Animals / Gene transfer techniques / Male / Immunosuppression / Adeno-associated virus / Duchenne Muscular Dystrophy / Skeletal Muscle / Degeneration / Dystrophin / Gene Transfer / Female / Animals / Gene transfer techniques / Male / Immunosuppression / Adeno-associated virus / Duchenne Muscular Dystrophy / Skeletal Muscle / Degeneration / Dystrophin / Gene Transfer

Partial cure of established disease in an animal model of metachromatic leukodystrophy after intracerebral adeno-associated virus-mediated gene transfer

Genetics / Gene Therapy / Immunohistochemistry / Biological Sciences / Brain / Mice / Animals / Central Nervous System / Animal Model / Adeno-associated virus / Enzyme / Brain Chemistry / Knockout Mice / Schwann Cell / Direct Injection / Gangliosides / Gene Transfer / Injections / Motor activity / Mice / Animals / Central Nervous System / Animal Model / Adeno-associated virus / Enzyme / Brain Chemistry / Knockout Mice / Schwann Cell / Direct Injection / Gangliosides / Gene Transfer / Injections / Motor activity

In Utero Delivery of Adeno-Associated Viral Vectors: Intraperitoneal Gene Transfer Produces Long-Term Expression

Technology / Gene Therapy / Gene expression / Genetic Engineering / Biological Sciences / Molecular / Pregnancy / Mice / Female / Animals / Gene transfer techniques / Animal Model / Adeno-associated virus / Behavioral Animal Models / Gene Delivery / Fetus / Transgene Expression / Molecular Targeted Therapy / Whole Body / Peritoneal Cavity / Gene Transfer / Molecular / Pregnancy / Mice / Female / Animals / Gene transfer techniques / Animal Model / Adeno-associated virus / Behavioral Animal Models / Gene Delivery / Fetus / Transgene Expression / Molecular Targeted Therapy / Whole Body / Peritoneal Cavity / Gene Transfer

Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats

Technology / Gene Therapy / Biological Sciences / Molecular / Liver / Animals / Gene transfer techniques / Polymerase Chain Reaction / Adeno-associated virus / Bilirubin / Rats / First Year / Crigler-Najjar syndrome / Rat Model / Molecular Targeted Therapy / Brain Damage / Serotyping / Bile / Animals / Gene transfer techniques / Polymerase Chain Reaction / Adeno-associated virus / Bilirubin / Rats / First Year / Crigler-Najjar syndrome / Rat Model / Molecular Targeted Therapy / Brain Damage / Serotyping / Bile

Novel Adeno-Associated Virus Serotypes Efficiently Transduce Murine Photoreceptors

Virology / Biological Sciences / Mice / Animals / Retina / Adeno-associated virus / Rhodopsin / Serotyping / Adeno-associated virus / Rhodopsin / Serotyping

SERCA2a Gene Transfer Enhances eNOS Expression and Activity in Endothelial Cells

Technology / Confocal Microscopy / Western blotting / Biological Sciences / Heart Failure / Cell line / Humans / Endothelial Cells / Congestive Heart Failure / Nitric oxide / Female / Animals / Gene transfer techniques / Endoplasmic Reticulum / Adeno-associated virus / Immunoprecipitation / Calcium Homeostasis / Endothelial Function / Endothelial cell / Swine / Protein Expression / Coronary Artery Disease / Vascular Reactivity / Molecular Targeted Therapy / Gene Transfer / Mitral regurgitation / Cell line / Humans / Endothelial Cells / Congestive Heart Failure / Nitric oxide / Female / Animals / Gene transfer techniques / Endoplasmic Reticulum / Adeno-associated virus / Immunoprecipitation / Calcium Homeostasis / Endothelial Function / Endothelial cell / Swine / Protein Expression / Coronary Artery Disease / Vascular Reactivity / Molecular Targeted Therapy / Gene Transfer / Mitral regurgitation

SERCA2a Gene Transfer Enhances eNOS Expression and Activity in Endothelial Cells

Technology / Confocal Microscopy / Western blotting / Biological Sciences / Heart Failure / Cell line / Humans / Endothelial Cells / Congestive Heart Failure / Nitric oxide / Female / Animals / Gene transfer techniques / Endoplasmic Reticulum / Adeno-associated virus / Immunoprecipitation / Calcium Homeostasis / Endothelial Function / Endothelial cell / Swine / Protein Expression / Coronary Artery Disease / Vascular Reactivity / Molecular Targeted Therapy / Gene Transfer / Mitral regurgitation / Cell line / Humans / Endothelial Cells / Congestive Heart Failure / Nitric oxide / Female / Animals / Gene transfer techniques / Endoplasmic Reticulum / Adeno-associated virus / Immunoprecipitation / Calcium Homeostasis / Endothelial Function / Endothelial cell / Swine / Protein Expression / Coronary Artery Disease / Vascular Reactivity / Molecular Targeted Therapy / Gene Transfer / Mitral regurgitation

AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression

Immune response / Gene Therapy / Apoptosis / Gene expression / Colorectal cancer / Biological Sciences / Cell line / Humans / Mice / Female / Animals / Cell Death / Cytochrome C / Adeno-associated virus / Gene Delivery / Colon cancer / Hepatocytes / Tumor necrosis factor-alpha / Tumor Necrosis Factor–α (TNF) / Gene Transfer / Biological Sciences / Cell line / Humans / Mice / Female / Animals / Cell Death / Cytochrome C / Adeno-associated virus / Gene Delivery / Colon cancer / Hepatocytes / Tumor necrosis factor-alpha / Tumor Necrosis Factor–α (TNF) / Gene Transfer

Anterograde Axonal Transport of AAV2-GDNF in Rat Basal Ganglia

Technology / Gene expression / Subthalamic Nucleus / Biological Sciences / Molecular / Animals / Male / Glial Cell / Substantia nigra / Adeno-associated virus / Rats / Globus Pallidus / Degeneration / Basal ganglia / Molecular Targeted Therapy / Course of Action / Parkinson Disease / Animals / Male / Glial Cell / Substantia nigra / Adeno-associated virus / Rats / Globus Pallidus / Degeneration / Basal ganglia / Molecular Targeted Therapy / Course of Action / Parkinson Disease

AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression

Immune response / Gene Therapy / Apoptosis / Gene expression / Colorectal cancer / Biological Sciences / Cell line / Humans / Mice / Female / Animals / Cell Death / Cytochrome C / Adeno-associated virus / Gene Delivery / Colon cancer / Hepatocytes / Tumor necrosis factor-alpha / Tumor Necrosis Factor–α (TNF) / Gene Transfer / Biological Sciences / Cell line / Humans / Mice / Female / Animals / Cell Death / Cytochrome C / Adeno-associated virus / Gene Delivery / Colon cancer / Hepatocytes / Tumor necrosis factor-alpha / Tumor Necrosis Factor–α (TNF) / Gene Transfer

Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats

Technology / Gene Therapy / Biological Sciences / Molecular / Liver / Animals / Gene transfer techniques / Polymerase Chain Reaction / Adeno-associated virus / Bilirubin / Rats / First Year / Crigler-Najjar syndrome / Rat Model / Molecular Targeted Therapy / Brain Damage / Serotyping / Bile / Animals / Gene transfer techniques / Polymerase Chain Reaction / Adeno-associated virus / Bilirubin / Rats / First Year / Crigler-Najjar syndrome / Rat Model / Molecular Targeted Therapy / Brain Damage / Serotyping / Bile

Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in canines

Technology / Biological Sciences / Molecular / Dogs / Animals / Heart / Animal Model / Adeno-associated virus / Myocardium / ENDOTHELIUM / Molecular Targeted Therapy / Plasmid DNA / Gene Transfer / single stranded DNA / Heart / Animal Model / Adeno-associated virus / Myocardium / ENDOTHELIUM / Molecular Targeted Therapy / Plasmid DNA / Gene Transfer / single stranded DNA

Recombinant Adeno-Associated Virus Serotype 9 Leads to Preferential Cardiac Transduction In Vivo

Genetics / Gene Therapy / Electrocardiography / Mice / Animals / Heart / Adeno-associated virus / Heart Disease / Clinical Sciences / Gene Delivery / Mouse Model / Skeletal Muscle / Circulation / Genetic Recombination / Gene Transfer / Serotyping / Heart / Adeno-associated virus / Heart Disease / Clinical Sciences / Gene Delivery / Mouse Model / Skeletal Muscle / Circulation / Genetic Recombination / Gene Transfer / Serotyping
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